[Histonet] RE: CAP Annual Results Comparison for FISH/ISH

[joelle weaver]

Thank you Dr. Cartun, these numbers are helpful for reference 




Joelle Weaver MAOM, HTL (ASCP) QIHC
 
> From: Richard.Cartun <@t> hhchealth.org
> To: oneilb <@t> wvuhealthcare.com; histonet <@t> lists.utsouthwestern.edu
> Date: Fri, 14 Mar 2014 20:01:54 +0000
> CC: 
> Subject: [Histonet] RE: CAP Annual Results Comparison for FISH/ISH
> 
> I'm not aware of published benchmarks for FISH/ISH, but if you're doing IHC for ER, PR, and HER2 in breast CA you may find the following information useful:
> 
> Lal P, et al:  ER and PR and histologic features in 3,655 invasive breast carcinomas.  Am J Clin Pathol 2005;123:541-546.
> 
> ER+ tumors - 74%
> PR+ tumors - 49
> HER2+ tumors - 16%
> 
> 
> Fitzgibbons PL, et al:  Recommendations for validating ER and PR IHC assays.  Arch Pathol Lab Med 2010;134:930-935.
> 
> For women over 65 years of age, the % of negative cases should not exceed 20%.
> For "low-grade" invasive carcinomas, the proportion of negative cases should not exceed 5%.
> 
> 
> My own data for invasive breast CA:
> 
> ER+ tumors - 85%
> PR+ tumors - 70%
> HER2+ tumors - 14%
> 
> 
> Please keep in mind that with the introduction of new monoclonal antibodies, more sensitive detection systems, and the "recommendation" that tumors with "1%" immunoreactive cells be called "Positive", the "old" benchmarks for ER and PR are no longer valid.
> 
> Richard
> 
> Richard W. Cartun, MS, PhD
> Director, Histology & Immunopathology
> Director, Biospecimen Collection Programs
> Assistant Director, Anatomic Pathology
> Hartford Hospital
> 80 Seymour Street
> Hartford, CT  06102
> (860) 972-1596 Office
> (860) 545-2204 Fax
> richard.cartun <@t> hhchealth.org
> 
> 
> 
> 
> -----Original Message-----
> From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of O'neil, Beth
> Sent: Wednesday, March 12, 2014 2:41 PM
> To: histonet <@t> lists.utsouthwestern.edu
> Subject: [Histonet] CAP Annual Results Comparison for FISH/ISH
> 
> Would fellow Histonetters be able to explain how they answer the following CAP question:
> ANP.22970 For immunohistochemical and FISH/ISH tests that provide independent predictive information, the laboratory at least annually compares its patient results with published benchmarks, and evaluates interobserver variability among the pathologists in the laboratory.
> Where would one even find published benchmarks?  Thank you
> 
> Beth Ann O'Neil, MT(ASCP)SC, HTL, QIHC
> Histology Supervisor/Technical Specialist West Virginia University Hospitals oneilb <@t> wvuhealthcare.com
> 304-293-7629 (office)
> 304-293-6014 (lab)
> 
> 
> 
> 
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