[Histonet] RE: HER2/NEU

[joelle weaver]

Consider the ASCO-CAP guideline and scoring changes for Her2/ FISH, not sure of the timeframe for your trend in increased positives, but my pathologist has indicated that I should expect more positive and equivocal cases, so perhaps related to categorizing of DX, rather performance or clone related.? see if that correlates




Joelle Weaver MAOM, HTL (ASCP) QIHC
 
> From: mward <@t> wakehealth.edu
> To: DKnutson <@t> primecare.org; histonet <@t> lists.utsouthwestern.edu
> Date: Wed, 15 Jan 2014 17:04:10 +0000
> CC: 
> Subject: [Histonet] RE: HER2/NEU
> 
> That is an interesting observation, as we have seen something of the same thing and we use the Dako Herceptest.    I would be interested in hearing others responses as well.   Thank you for asking the  question.
> 
> 
>  
> Martha Ward, MT (ASCP) QIHC
> Manager
> 
> Molecular Diagnostics Lab
> Medical Center Boulevard  \  Winston-Salem, NC 27157
> p 336.716.2109  \  f 336.716.5890  
> mward <@t> wakehealth.edu  
>  
>  
> 
> 
> 
> -----Original Message-----
> From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Knutson, Deanne
> Sent: Wednesday, January 15, 2014 11:46 AM
> To: 'histonet <@t> lists.utsouthwestern.edu'
> Subject: [Histonet] HER2/NEU
> 
> I just wanted to see what others in the histology world might be experiencing.
> 
> We have seen a marked increase in the percentage of HER2 cases resulting as Indeterminate, when we compare our last year patient predictive marker results to this year's results.
> The clone we are using is CB11 from Cell Marque.
> 
> We did a HER2 study last year where we sent out our cases for a second opinion, and the study showed others interpreted our Indeterminates as that also.
> Has anyone else also noted this increase in their annual comparison, and what clone are you using?
> 
> It is so nice to be able to reach out to our peers with these types of questions.
> Thank you for responding back!
> 
> Deanne Knutson
> Anatomic Pathology Supervisor
> St. Alexius Medical Center
> 701-530-6730
> dknutson <@t> primecare.org<mailto:dknutson <@t> primecare.org>
> 
> 
> 
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