[Histonet] Thalamic lesions in Alzheimer mice
benoit.delatour <@t> ibaic.u-psud.fr
Tue Jan 3 10:09:31 CST 2006
First of all, happy new year!
I was wondering if one of you may have an idea concerning a very
curious lesion we recently observed in the thalamus of "Alzheimer"
(APP) transgenic mice. Most specifically these lesions are located in
the ventral posterior complex (Ventral postero lateral (VPL) and
Ventral postero medial (VPM) nuclei). They do not seem to be visible
in other brain regions.
Results from neuropathological examination are the following:
-These lesions are mainly associated with VPL/VPM amyloid deposits
(plaques) and have a cristal-like appearance with a Nissl stain.
-They are positive for iron (PERLS-DAB) and calcium (Alizarine red)
-They do not seem to be associated with vascular abnormalities (fact.
VIII IHC) or enhanced inflammatory reaction (lectin IHC).
If someone has been confronted with similar observations or has any
ideas/suggestions concerning the origin / pathological mechanism
associated to / identification of such neuropathological
alterations... (I can send microphotos to anyone interested).
Thanks in advance!
_______________________________ B. Delatour
Laboratoire de Neurobiologie de l'Apprentissage,
de la Mémoire & de la Communication,
NAMC, CNRS UMR 8620, Bât 446
91405 Orsay Cedex, FRANCE
Email benoit.delatour <@t> ibaic.u-psud.fr
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