[Histonet] Decreased antigenicity with alcohol-formalin fixation

[Goodwin, Diana]

> Greetings, Histonetters.
> 
> One of my pathologists has expressed concern that antigenicity for certain
> antibodies, specifically ER and PR, in breast tissue that is processed
> using alcohol-formalin will be decreased.  Can anyone cite a reference in
> the literature that confirms or addresses this concern?  Has anyone had
> this experience, or does anyone know of any reason that using
> alcohol-formalin (specifically Pen-Fix) would adversely affect IHC
> staining?
> 
> Thanks to all of you,
> 
> Diana Goodwin
> Supervisor, Anatomic Pathology
> Preston 6
> 215-829-6532
> e-mail:  goodwind <@t> pahosp.com
> 
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