[Histonet] C4D control

[Sheeder, Christopher]

Hi Tony,
Thanks for the info.
My pathologists wanted to see if we could find any positive heart tissue before resorting to placenta.
We had a positive transplant case a couple of years ago, so they are a little spoiled.

Best,
Chris

Christopher Sheeder, HT(ASCP)CMQIHC
Histology / Pathology Administration Supervisor | Department of Laboratories
Seattle Children’s Hospital
4800 Sand Point Way NE
Seattle, WA 98105

Office: 206-987-6259

christopher.sheeder at seattlechildrens.org<mailto:renu.jain at seattlechildrens.org>

WWW      seattlechildrens.org
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From: Tony Henwood <afhenwood at outlook.com>
Sent: Saturday, October 24, 2026 2:49 PM
To: histonet at lists.utsouthwestern.edu; Sheeder, Christopher <Christopher.Sheeder at seattlechildrens.org>
Subject: Re: C4D control

Hello Christopher. Since C4d-positive kidney and heart controls are often difficult to source, it might be useful to consider placenta (Chronic Histiocytic Intervillositis) or skin with bullous pemphigoid. References as follows: Chan, E. S. ,

Hello Christopher.

Since C4d-positive kidney and heart controls are often difficult to source, it might be useful to consider placenta (Chronic Histiocytic Intervillositis) or skin with bullous pemphigoid. References as follows:

Chan, E. S., de Koning, L., Yu, W., & Chadha, R. (2023). C4d staining is present in normal placentas from pregnancies prior to pregnancy loss associated with chronic histiocytic intervillositis and is reduced by immunomodulatory therapy in subsequent pregnancies. Pediatric and Developmental Pathology, 26(4), 374-387.

Chandler, W., Zone, J., & Florell, S. (2009). C4d immunohistochemical stain is a sensitive method to confirm immunoreactant deposition in formalin‐fixed paraffin‐embedded tissue in bullous pemphigoid. Journal of cutaneous pathology, 36(6), 655-659.




Regards,



Tony Henwood MSc, BAppSc, GradDipSysAnalys, CT(ASC), FFSc(RCPA) (Retired)

Principal Scientist, the Children’s Hospital at Westmead (Retired)

Adjunct Fellow, School of Medicine, University of Western Sydney.


________________________________
From: Sheeder, Christopher via Histonet <histonet at lists.utsouthwestern.edu<mailto:histonet at lists.utsouthwestern.edu>>
Sent: Saturday, October 24, 2026 04:07
To: histonet at lists.utsouthwestern.edu<mailto:histonet at lists.utsouthwestern.edu> <histonet at lists.utsouthwestern.edu<mailto:histonet at lists.utsouthwestern.edu>>
Subject: [Histonet] C4D control

Good morning all,

I am in need of a heart tissue control block that is C4D positive.
Willing to negotiate price/trade.

Thanks


Christopher Sheeder, HT(ASCP)CMQIHC

Histology / Pathology Administration Supervisor | Department of Laboratories

Seattle Children’s Hospital

4800 Sand Point Way NE

Seattle, WA 98105



Office: 206-987-6259



christopher.sheeder at seattlechildrens.org<mailto:renu.jain at seattlechildrens.org<mailto:christopher.sheeder at seattlechildrens.org%3cmailto:renu.jain at seattlechildrens.org>>



WWW      seattlechildrens.org

COMPASSION | EXCELLENCE | INTEGRITY | COLLABORATION | EQUITY | INNOVATION





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