[Histonet] Cryotomy help

[Charles Riley]

I have a researcher who is trying to mass spectrometry on frozen tissue
sections. They submitted the sample in methanol and even after sitting in a
-80 freezer overnight the samples are too soft to section.

Does anyone have any tips on how to harden the tissue for sectioning that
won't damage the results for mass spect (I was thinking liquid nitrogen but
want to be sure it won't damage the results)?