[Histonet] Warm formalin

[Lynette Pavelich]

Carl,
My only other thought is to do a documented study of the temperature of these outside storage boxes (they can be little hot/cold boxes depending on your location. Because, according to the inspectors, you must be able to assure temperature is within the required temps prior to receiving, including transportation. (Pre-analytical)
So, say you do a study of the temperatures during the hottest time of the day of the boxes for a period of time (30 days of the hottest month(s)) to give an indication of a potential problem, and document. That would be one portion of pre-analytical. 

Then temperature during transportation (cars/vans can get quite hot/cold also needs to be addressed and documented daily just like the temperature logs in the labs. Many labs are getting cited for not providing good pre-analytical evidence. Courier services have to have temperature monitoring systems in place to provide as evidence. Some are quite savvy with alarm systems in place with monitoring. (ShipCom for example)

So much documentation these days……

Lynette


> On Jul 22, 2020, at 2:27 PM, Hobbs, Carl <carl.hobbs at kcl.ac.uk> wrote:
> 
> You a re right, Lynette
> De rigueur for Diagnostic labs!
> My apologies for forgetting that ( I am now in research labs where...it is less restricted, unfortunately).
> Essential to be well-documented/adherent to SOPs.
> Respectful-illy
> 
> Carl
> 
> 
> Carl Hobbs FIBMS
> Histology and Imaging Manager
> Wolfson CARD
> Guys Campus, London Bridge 
> Kings College London
> London
> SE1 1UL
>  
> 
> 020 7848 6813
> 
> 
> From: Lynette Pavelich <lynettepav at gmail.com>
> Sent: 22 July 2020 19:19
> To: Hobbs, Carl <carl.hobbs at kcl.ac.uk>
> Cc: histonet at lists.utsouthwestern.edu <histonet at lists.utsouthwestern.edu>
> Subject: Re: [Histonet] Warm formalin 
>  
> I would suggest to always refer to your reagent’s IFU insert. This will advise at what temperature you should use/store. All inspectors (CAP, JC, CLIA, etc.) will make you adhere to these specifications. 
> Unless you do a well documented validation study that goes outside of these restrictions from the IFU that proves no patient harm, you honestly must go by the IFU recommendations. This would apply to all of our stains/reagents/solutions/antibodies.
> Our world is becoming more restrictive……
> 
> hope this helps,
> Lynette Pavelich, HT(ASCP), QIHC
> 
> 
>> On Jul 22, 2020, at 1:55 PM, Hobbs, Carl via Histonet <histonet at lists.utsouthwestern.edu> wrote:
>> 
>> Depends on what you are doing with the sections.
>> IHC or just dye -staining?
>> Sure...too hot ( cooking) is not recommended, as stated
>> Also stated is that high -temp fixation may also be used with no deleterious effects as long as the fixation time is not extended.
>> However, RT -ish even for a week won't be a problem...imho
>> Needs must?
>> 
>> 
>> 
>> Carl Hobbs FIBMS
>> Histology and Imaging Manager
>> Wolfson CARD
>> Guys Campus, London Bridge 
>> Kings College London
>> London
>> SE1 1UL
>> 
>> 
>> 020 7848 6813
>> _______________________________________________
>> Histonet mailing list
>> Histonet at lists.utsouthwestern.edu
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