[Histonet] Cellient for cell block preparation

[Bob Richmond]

Richard w. Cartun, MS, PhD, at Hartford [CT] Hospital asks:

>>What has been your experience with  Hologic's Cellient instrument for
preparing cell block specimens?  I understand that it is very good for
pauci-cellular specimens.  However, I am concerned about using these
preparations for immunohistochemical and DNA/RNA testing.<<

This instrument requires fixation of the specimen in ThinPrep's CytoLyt®,
an alcohol-based fixative. They specifically note in their documentation
that formalin cannot be used.

I found a recent (3 years ago) review that addresses the issue:
https://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2016-0125-RA

Marty Berman was chief resident at Johns Hopkins during my second year in
pathology residency there, in 1965.

Bob Richmond
Samurai Pathologist
Maryville TN