[Histonet] Kappa and Lambda by ISH

[Greg Dobbin]

Hi Folks,
As it happens, we had a lymphoma case this week that was Kappa restricted
(confirmed at a consulting laboratory by Flow Cytometry) and our Kappa and
Lambda ISH staining was negative for both! In discussing it further with
our Hematopathologist, our ISH probes for Kappa and Lambda in bone marrow
specimens only stains plasma cells it does *NOT* stain B-cells. So this is
likely why LN tend to be negative. Maybe one of our Histonet-contributing
pathologists would like to elaborate? :-)
Greg

-- 
*Greg Dobbin*
Chief Technologist,
Anatomic Pathology
Dept. of Laboratory Medicine,
Queen Elizabeth Hospital,
P.O. Box 6600
Charlottetown, PE    C1A 8T5
Phone: (902) 894-2337
Fax: (902) 894-2385


*Everything in moderation...even moderation itself**!*