[Histonet] ALK IHC

[Cartun, Richard]

We are in the process of bringing this on-line.  We are using a rabbit monoclonal (clone D5F3) from Cell Signaling Technologies (Danvers, MA).  There are cases that are obviously positive and then there cases that are "Equivocal" (like HER2) where you need to do the FISH test.  The advantages of the IHC are less cost, faster result, can be used on specimens with limited tumor cells present, and it may prove useful for those tumors that show genomic heterogeneity.

Richard

Richard W. Cartun, MS, PhD
Director, Histology & Immunopathology
Director, Biospecimen Collection Programs
Assistant Director, Anatomic Pathology
Hartford Hospital
80 Seymour Street
Hartford, CT  06102
(860) 972-1596
(860) 545-2204 Fax

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Mark Tarango
Sent: Thursday, October 23, 2014 4:41 PM
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] ALK IHC

Does anyone stain lung cancer specimens for ALK using IHC?  If not, any opinions?

thanks

Mark
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