[Histonet] Minimum sample size for breast markers

Martha Ward-Pathology mward <@t> wakehealth.edu
Thu Sep 12 09:24:10 CDT 2013

Thanks Rene.  I realize that it is ultimately up to the Pathologist but I was wondering if there are any written guideline/suggestions because I have had pathologists ask me if there is minimum.

From: Rene J Buesa [mailto:rjbuesa <@t> yahoo.com]
Sent: Thursday, September 12, 2013 9:23 AM
To: Martha Ward-Pathology; histonet <@t> lists.utsouthwestern.edu
Subject: Re: [Histonet] Minimum sample size for breast markers

I do not think this is the adequate forum to ask this question because you may get a wrong answer that could determine your decision.
Your pathologist is the one who should decide about this issue.
René J.

From: Martha Ward-Pathology <mward <@t> wakehealth.edu<mailto:mward <@t> wakehealth.edu>>
To: "histonet <@t> lists.utsouthwestern.edu<mailto:histonet <@t> lists.utsouthwestern.edu>" <histonet <@t> lists.utsouthwestern.edu<mailto:histonet <@t> lists.utsouthwestern.edu>>
Sent: Thursday, September 12, 2013 9:06 AM
Subject: [Histonet] Minimum sample size for breast markers

Is there a minimum number of cells that should be present when testing for ER, PR and Her2? I have looked on the CAP website but cannot see anything about this.  We are constantly getting these small biopsies or FNAs for testing and I sometimes wonder what the lowest threshold is for testing...20 tumor cells, 50 tumor cells????  Any information would be appreciated.  Thanks in advance for your help.

Martha Ward, MT (ASCP) QIHC

Molecular Diagnostics Lab
Medical Center Boulevard  \  Winston-Salem, NC 27157
p 336.716.2109  \  f 336.716.5890
mward <@t> wakehealth.edu<mailto:mward <@t> wakehealth.edu>

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