[Histonet] Fluorochrome bone labeling in dogs

[Malandra, Allison E]

Good afternoon -



Our lab is planning an upcoming study that involves using fluorochrome bone labels in hound dogs.  One is oxytetracycline at 30 mg/kg IV.   Back when I was a young veterinarian, I took care of two dogs that went into acute renal failure after they were given that dose. I know that oxytet is widely used as a bone label in dogs but the nephrotoxicosis has been reported in several citations.  A PubMed search revealed a wide range of dosing of oxytet for bone labeling in dogs (usually between 10-30 mg/kg) used IV, SQ or IM.



Can anyone share their oxytetracycline labeling protocol for dogs? We would prefer to not give it IV if possible but I have heard of granulomas forming IM. Has anyone experienced the renal toxic effects? I believe one paper looked at giving parenteral fluids at time of administration to help with diuresis but I am awaiting inter-library loan delivery for the full citation.



I appreciate everyone's time and help.



Allison Malandra, DVM

Bone Healing Research Lab

University of Iowa




________________________________
Notice: This UI Health Care e-mail (including attachments) is covered by the Electronic Communications Privacy Act, 18 U.S.C. 2510-2521, is confidential and may be legally privileged.  If you are not the intended recipient, you are hereby notified that any retention, dissemination, distribution, or copying of this communication is strictly prohibited.  Please reply to the sender that you have received the message in error, then delete it.  Thank you.
________________________________