[Histonet] RE: [IHCRG] ER clone 1D5 or SP1 ?

Mon Apr 26 17:11:55 CDT 2010

Thanks Michael ----I saw table 10 -but on page 16 they specifically only
list clone 1294 and 312 (which is whose?) -they really don't clearly say
all clones for PR listed in table 10.  They also only refer to these two
again on the shortened ASCO color plate handout Additional information
in re: clinical question 2.1.  Deb

________________________________

From: Michael Ho [mailto:michael.ho <@t> sickkids.ca] 
Sent: Monday, April 26, 2010 4:13 PM
To: Van Eyck, Deb; ancillarypath <@t> mac.com; ihcrg Group (E-mail); histonet
netserver
Subject: RE: [IHCRG] ER clone 1D5 or SP1 ?

Hi Deb

If you look at table 10 of the new guidelines you will see the ER/PR
antibody clone list

Michael

________________________________

From: ihcrg <@t> googlegroups.com [ihcrg <@t> googlegroups.com] On Behalf Of Van
Eyck, Deb [deb.vaneyck <@t> phci.org]
Sent: April 26, 2010 12:29 PM
To: ancillarypath <@t> mac.com; ihcrg Group (E-mail); histonet netserver
Subject: RE: [IHCRG] ER clone 1D5 or SP1 ?

This is a great discussion lets also talk about PR clones since the
ASCO/CAP guidelines just came out ------Hadi or Rich I know they only
list two PR clones one is Dako 1294-----what is the other 312? Deb

________________________________

From: ihcrg <@t> googlegroups.com [mailto:ihcrg <@t> googlegroups.com] On Behalf
Of ancillarypath <@t> mac.com
Sent: Sunday, April 25, 2010 7:36 PM
To: ihcrg Group (E-mail); histonet netserver
Subject: Re: [IHCRG] ER clone 1D5 or SP1 ?

When we started our lab 3 years ago, we began with SP1 from day 1, so I
don't have any experience with either 1D5 or 6F11 except in my previous
labs. 1D5 is an excellent clone, and seems to be more specific than SP1
in the work-up of metastatic carcinoma of unknown primary site, based on
the published literature. The advantage of 6F11 is that, for those of us
who use the Allred scoring system, it's the only clone that was
clinically validated by Harvey et al. (JCO 1999) for this purpose. I
agree with Rich.

For those who use SP1, it's a very good clone as a predictive marker in
breast cancer. But again, in the setting of metastatic workup, it is NOT
recommended, as it will pick up too many primary lung cancers and some
colon cancers (personal experience).

Hadi

================================

Hadi Yaziji, M.D., Medical Director

Vitro Molecular Laboratories

President,

Ancillary Pathways

7000 62nd Avenue, PH-C

Miami, FL 33143

T 305-740-4440

F. 786-513-0175

www.vitromolecular.com

www.ancillarypath.com

On Apr 25, 2010, at 3:04 PM, Richard Cartun wrote:

I have looked at several clones over the years and I prefer clone 6F11.

Richard

Richard W. Cartun, Ph.D.
Director, Histology & Immunopathology
Director, Biospecimen Collection Programs
Assistant Director, Anatomic Pathology
Hartford Hospital
80 Seymour Street
Hartford, CT  06102
(860) 545-1596 Office
(860) 545-2204 Fax

		"Taylor, Jean" <jtaylor <@t> meriter.com> 4/23/2010 11:17 AM
>>>

I'm wondering which clone of ER most labs are using?

Thanks,
Jean Taylor, HT(ASCP)QIHC
IHC Tech
Meriter Health Services
Madison, WI

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