[Histonet] missing melanocytes??

[Kathleen Roberts]

There is such a thing as "amelanotic melanoma"...since this only happens 
on a rare occasion, maybe this is it?  I would think that the 
pathologists would know, though.  (We have a professor here who studies 
both melanoma and the amelanotic variety, and I did the histo for her 
for a while-that's how I know about it.)  Just a thought.

Kathleen Roberts
Rutgers University, NJ

Histonet wrote:

> You say "they are unable to see the melanocytes". Or is it just the 
> melanin granules that are "missing"? Are other cells and structures 
> staining normally? Do the granules appear if you use Masson-Fontan or 
> some other melanin demonstration technique? Do the problem specimens 
> all come from the same source (clinic, surgeon, etc).
> Are you sure you don't have a population of albinos in your region?
>
> Paul Bradbury
> Kamloops, Canada
>
> ?
> kristen arvidson wrote:
>
>> Help!! Our pathologists are starting to see a new artifact where they 
>> are unable to see the melanocytes (we are all derm).  It only happens 
>> on a rare occasion.  We checked the PH of the water on the stainer 
>> and it seemed fine.  We can't think of anything else?  Help!
>>
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