[Histonet] Re: Lendrum stains
Ronald.Houston <@t> nationwidechildrens.org
Fri Jan 4 13:25:56 CST 2008
I fondly remember performing Lendrum's stains in a previous life back
home in Scotland. The color contrasts of many of the techniques remains
unsurpassed as far as tinctorial staining is concerned.
Not so sure why none of the methods really took off in the States;
perhaps you're right, Bob, it may have had to do with the fact that he
got many of the dyes directly from the mills.
Professor Alan C Lendrum was Professor of Pathology at both Glasgow and
Dundee Universities (the latter until 1972 when I believe he retired).
Perhaps John Bancroft, Peter Stoward and/or Richard Horobin would be
able to comment more on Professor Lendrum, if they still subscribe to
Histonet. It is certainly true that he was one of the last
histopathologists who understood the properties of the dyes and the
theory behind the techniques he introduced with his colleagues.
His work was true Art in histology; alas a dieing trait (no pun
As far as I am concerned, his MSB (Martius Yellow, Crystal Scarlet,
Soluble Blue) is still the best method for fibrin demonstration.
Ronnie Houston, MS, HT(ASCP)QIHC
Anatomic Pathology Manager
Nationwide Children's Hospital
700 Children's Drive
Columbus, OH 43205
(614) 722 5465
Ronald.Houston <@t> NationwideChildrens.org
Columbus Children's Hospital is now Nationwide Children's Hospital
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Robert
Sent: Friday, January 04, 2008 12:50 PM
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] Re: Lendrum stains
Sharon E. Willman (where?) asks for information about "Lendrun" and
Fraser stains, she doesn't say for what.
A.C. Lendrum, I was told back around 1970, was one of the last
histologists who understood textile dyes. Apparently there were a lot
of small factories making obscure dyes in Scotland back then, and he
knew all of these single malt dye-makers and collected numerous
samples. His eclectic habits make it difficult to identify the dyes he
used, let alone obtain and use them. That and the invention of
immunohistochemistry probably consign most of his work to oblivion.
Lendrum's "Obadiah" stain (he was fond of such fanciful names) for
fibrin was in use in a research lab at Cornell Medical Center on east
68th street in New York City when I was there briefly in 1968.
Stainsfile gives the following reference: Lendrum, A. C., et. al.
(1962) "Studies on the character and staining of fibrin." Journal of
Clinical Pathology, v. 15, p. 401. [this is a British journal, not the
AJCP]. Rotsa ruck finding naphthalene blue black CS, Chicago red, or
polar brilliant red BN.
John Kiernan - Dick Dapson - Mike Titford - other geezers on this list
- do you know anything more about A.C. Lendrum? He must have been an
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