[Histonet] Does BerEP4 go by any other name and who makes it?

koellingr <@t> comcast.net koellingr <@t> comcast.net
Fri Feb 23 16:52:56 CST 2007

Its tricky for a specific synonym but I believe BerEP4 (specificity uncharacterized) will turn out to be a clone that describes an epitope of what some call Ep-CAM (epithelial cellular adhesion molecule).  Look for Ep-CAM in Lab Vision or Abcam sites and they describe the 25+ and growing synonyms to Ep-CAM, BerEP4 being one of them. This is a glycoprotein in epithelia that was discovered in the 70's and with each new "discovery" gets another name.  Sort of like when you were reading journal articles in the 80's, all of which seemed curiously to be talking about the same cell or cellular phenotype, but each researcher having their own designation and it  was utterly confusing. Until they got the CD workshops going in the 80's and figured out that hundreds of labs, all calling their antibody clone or target by their own name, were actually describing the very same target (CD4, or CD5 or CD8, etc).  No one has taken the time to do such efficient catagorization with the molecules you a
re asking about but they are increasingly interesting to cancer biologists.  So  I think this nomenclature can of worms is soon to be worked out.  CD326 (EpCAM) is now a current nomenclature I believe.  It turns out that a clone that we developed and I worked on in grad school, that stained the surface of cells of high endothelial venules in lymph nodes, probably was just our name for this very target and we didn't realize it.  

no affiliation or employer yet (but almost do now so my golf playing free time is about over)
Seattle, WA

-------------- Original message -------------- 
From: "Kate Mendell" <KMENDELL <@t> nhs-healthlink.org> 

> Does BerEP4 go by any other name and who makes it? 
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