[Histonet] puzzling morphology

[Rogerson Kemlo (ELHT) Pathology]

It's not actually an absence of tissue is it? The spaces could be due to
virus, like koilocytotic atypia. It could also be an artefact as you
suggest but I can't figure what could cause perinuclear haloing as you
suggest, I would have thought cellular changes would have affected the
whole cell not just shrinking the nucleus. 

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Walters,
Katherine S
Sent: 23 August 2005 22:53
To: histonet <@t> pathology.swmed.edu
Subject: [Histonet] puzzling morphology

I am once again in need of some collective wisdom from the experts.

I have some paraffin embedded lung tissue in which the bronchial
endothelium cells exhibit "spaces" (around the nucleus) in the cytoplasm
in the H&E 5 micron section.  These were fixed with zinc formalin.

Does anyone know what would cause this absence of tissue?

Thanks again for your wisdom,
Kathy


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