[Histonet] formalin fixing

[Shibaji Shome]

Hi,
Stupid question of the day:

I would like to know how formalin fixation works. Does formalin enter 
the extracellular space and replace water? does it enter both extra and 
intracellular space? The shrinkage of tissue on formalin fixing is 
indicative of water loss and/or collapse of intracellular/extracellular 
space? Any information, pointers to references will be greatly 
appreciated. Details on working principles of formalin fixation will 
greatly, vastly appreciated.
Thanks!
Regards,
Shibaji