[Histonet] Collagen staining using special stains, lighter vs darker

[Madary, Joseph]

I have an investigator looking at Massons(with Aniline Blue), Van Gieson
and Gomori's all showing the same type of collagen staining.  In some
areas collagen fibers are brilliantly stained and other fibers are pale
all on the same slide.  This is consistent across the board so we know
it is not the stain, rather the tissue response.  I want to say I have
heard lighter collagen fibers are either immature or dying.  I mean that
is fine, but does anyone have any real answers?

 

Nick Madary, HT/HTL(ASCP)QIHC

Histology Mgr, Medimmune

301.398.6360(lab), 4745(vm),9745(fax)

 

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