[Histonet] to do or not to do egfr

[Weems, Joyce]

Don't we need to be sure that the FDA approved reagents are used? If not a
patient can be denied clinical trials. Joyce

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu]On Behalf Of Willis,
Donna
Sent: Thursday, March 11, 2004 9:57 AM
To: 'KHays <@t> mbhs.org'; histonet <@t> pathology.swmed.edu
Subject: RE: [Histonet] to do or not to do egfr


Kathy,
Just to let you know.  We have been using the DAKO Clone H11 on both the
Dako and Ventana instruments for a long time.  When we got a request from on
of our Oncologist in Feb for EGFR on archived colon cases we thought no
problem.  We used the H11 clone and everything was negative.  The oncologist
questioned the clone we were using and asked us to get the new EGFR pharmDx
clone 2-18C9 and retest the cases.  We did and they were positive.  Just
beware that if the patient is being tested for the Erbitux drug we all might
have to use the 2-18C9 clone.

Donna Willis
Histology Lab Manager
Harris Methodist Fort Worth, Tx

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu]On Behalf Of
KHays <@t> mbhs.org
Sent: Wednesday, March 10, 2004 4:33 PM
To: histonet <@t> pathology.swmed.edu
Subject: [Histonet] to do or not to do egfr


Kathy Tedford-Hays  HT (ASCP)
Technical Specialist, Histology Dept
(601)-968-3070 ext 7398
Baptist Medical Center
1225 North State Street
Jackson, MS 39202


we are currently getting several requests for the test egfr as many of 
you.  my questions are:  is this another immunostain or is this something 
more?
we were told that if the patients are positive then they are candidates 
for a new chemotherapy for colon cancer.   if this is not another 
immunostain then what labs are doing the egfr  for this new chemo?  any 
information would be appreciated.  thank you.

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