[Histonet] MMR

[Val T]

> Hey Karen
> 
> CAP doesn’t have a guideline for MMR (yet), like they do with breast markers.  However, there are some publications and antibody vendor inserts that address how formalin time affects MMR protein expression. (See links below).
> Ventana assay recommends 6-48hr window.
> 
> MMR panel is really starting to branch outside the colon and endometrial cancer umbrella. It is being used on a lot of different tumor types (including breast) for both therapeutic and prognostic indicators.

See study: "Impact of formalin fixation on mismatch repair”
Also see: MMR IHC Panel Interpretation Guide from Ventana
> 
> Val
> 
> 
>> On Mar 14, 2024, at 6:49 AM, Karen Schieberl CA-San Francisco via Histonet <histonet at lists.utsouthwestern.edu> wrote:
>> 
>> Good Morning,
>> I am looking for literature on minimum and maximum formalin time for breast
>> tissue for MMR testing.   I know about this time for ER/PR, HER2 and fish
>> testing.  I need the literature for the MMR fixation time on Breast
>> tissue.
>> 
>> I thought that you do not even do MMR on breast tissue.
>> 
>> Your help is greatly appreciated.
>> 
>> Thanks,
>> Karen Schieberl HT ASCP
>> 
>> Lead Histology Technician
>> 
>> St. Mary's Medical Center
>> 
>> 450 Stanyan St.
>> 
>> San Francisco, Ca. 94117
>> 
>> 415-750-5751
>> 
>> karen.schieberl@ <karen.schieberl at dignityhealth.org>commonspirit.org
>> 
>> 
>> 
>> 
>> Caution:  This email message, including all content and attachments, is
>> CONFIDENTIAL and may be of a nature that is LEGALLY PRIVILEGED.  The
>> information contained in this email message is intended only for the use of
>> the recipient(s) named above. If the reader of this message is not the
>> intended recipient or an agent responsible for delivering it to the
>> intended recipient, you have received this document in error.  Any further
>> review, dissemination, distribution, or copying of this message is strictly
>> prohibited.  If you have received this communication in error, please
>> notify us  immediately by reply email.  Thank you
>> 
>> Caution: This email is both proprietary and confidential, and not intended for transmission to (or receipt by) any unauthorized person(s). If you believe that you have received this email in error, do not read any attachments. Instead, kindly reply to the sender stating that you have received the message in error. Then destroy it and any attachments. Thank you.
>> _______________________________________________
>> Histonet mailing list
>> Histonet at lists.utsouthwestern.edu
>> http://lists.utsouthwestern.edu/mailman/listinfo/histonet