[Histonet] ER/PR question

[Bob Richmond]

Karen Heckford HT ASCP CE at St. Mary's Medical Center in San Francisco, CA
asks:

>>One of my pathologists wants me to do some ER/PR's on 9 year old tissue
blocks. I know ER and PR can be sensitive are the IHC's going to work or
will there be too much antigen decay?<<

You can only try. There should be some antigen positive ducts and what have
you in these 9 year old tissues that should serve as an internal control.
If there's nothing positive, I'd interpret negative results cautiously. But
it's worth a try.

Bob Richmond
Samurai Pathologist
Maryville TN