[Histonet] V600E

[Gudrun Lang]

This is an mutationspecific antibody against BRAF. And the mutation detected is called p.V600E. The exchange of an nucleotid in the
DNA (codon 600) leads to an tranformed and always activated BRAF-protein, that is sensitive to an thyrosinkinase-inhibitor as an eg.
Melanoma therapy. As far as I remember it was sold by Novus Biological before Roche-Ventana had it. The clone is VE1.

Gudrun

-----Ursprüngliche Nachricht-----
Von: Normington Lacy via Histonet [mailto:histonet at lists.utsouthwestern.edu] 
Gesendet: Mittwoch, 6. Juni 2018 16:43
An: Laurie Colbert; 'histonet at lists.utsouthwestern.edu'
Cc: jtouchstone at pathmdlabs.com
Betreff: Re: [Histonet] V600E

I am thinking this might be BRAF, clone V600E.  We get ours from Ventana Roche.

Lacy Normington
UW Health 
Madison, WI


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From: Laurie Colbert via Histonet [mailto:histonet at lists.utsouthwestern.edu] 
Sent: Wednesday, June 06, 2018 8:50 AM
To: histonet at lists.utsouthwestern.edu
Cc: jtouchstone at pathmdlabs.com
Subject: [Histonet] V600E

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Can anyone tell me about the V600E antibody?  Our pathologist wants to add it to our menu of IHC stains, and I've never heard of it.
Sources?

Thanks,
Laurie Redmond
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