[Histonet] Translational science/medicine/research IHC lab question

[Katy Milne]

I run the histology lab at the Deeley Research Centre in Victoria BC, we're a combination of basic research (mostly mouse projects) and translational research (often samples from clinical trials and other human-based research projects).

Translational research is just really the bridge between bench and bedside so you're looking mostly at human samples where the outcome of the research could translate into downstream benefits to human health.

It's hard to say what advice I would have for setting up a translational lab but you can certainly hit me up offline with any questions you may have and I can help where I can.

As for equipment you'd basically have what you have in a basic IHC lab.  Beyond that it would depend on what sort of services you want to offer.  We do a lot of multicolour IHC so we have a multispectral imaging system (Vectra) and we have automated scoring software (Inform) as a lot of our clients don't have an in-house pathologist available to them so they just want an excel file of counts at the end of the day.  We also do multicolour IF so we use the same system for that.  We've also been working on developing the molecular end of things with ISH and in situ PCR, possibly Nanostring down the road but typically these have been backburnered as we've been so busy with the multicolour IHC projects.

Good luck!

Katy Milne
Molecular and Cellular Immunology Core
Trev and Joyce Deeley Research Centre

Message: 3
Date: Thu, 28 Sep 2017 22:14:16 +0000
From: Judi Ford <jford at cytomx.com>
To: "histonet at lists.utsouthwestern.edu"
	<histonet at lists.utsouthwestern.edu>
Subject: [Histonet] Translational science/medicine/research IHC lab
	question
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Hi Everyone,
I am interested in connecting with techs/managers who are working in or have developed a translation science/medicine/research IHC lab. Recently my department has become a translational science department and I run most of the IHC. I'm interested in building this lab into a good translational ihc lab and was wondering about the following:

1.       What does being a translational ihc lab mean?

2.       What advice would you have in building a translational ihc lab?

3.       What equipment would you want in a translational ihc lab that isn't necessarily in a regular research ihc lab?

4.       Are you available offline for further questions?
I really appreciate any guidance you send my way. I'm looking at this as a long term goal with the possibility of becoming the manager of the lab.
Thanks sooooo much in advance for any advice.  Hope you all have a really great weekend :) Best regards, Judi Gordon SRA Translational Sciences CytomX Therapeutics South San Francisco, CA