[Histonet] ANP.22970 Annual Result Comparison

Jamal Rwaihi j.rowaihi at alborglaboratories.com
Sun Jun 5 10:43:12 CDT 2016


Good day colleagues 

 

I need your help in collecting the data for the bellow requirements for CAP,
is their good reference to collect the benchmark statistics for ER, PR &
Her2neu ?

 

 


ANP.22970

Annual Result Comparison

 	

 

For immunohistochemical and FISH/ISH tests that provide independent
predictive information, the laboratory at least annually compares its
patient results with published benchmarks, and evaluates interobserver
variability among the pathologists in the laboratory.

NOTE: Individuals interpreting the assay must also have their concordance
compared with each other and this concordance should also be at least 95%.

With specific reference to estrogen and progesterone receptor studies: in
general, the overall proportion of ER-negative breast cancers (invasive and
DCIS) should not exceed 30%. The proportion is somewhat lower in
postmenopausal than premenopausal women (approximately 20% vs. 35%). The
proportion is considerably lower in well-differentiated carcinomas (<10%)
and certain special types of invasive carcinomas (<10% in lobular, tubular,
and mucinous types). The proportion of PgR-negative cases is 10-15% higher
than for ER-negative in each of these settings. Investigation is warranted
if the proportion of negative cases is significantly lower in any of these
settings.

 

 

Jamal M. Al Rowaihi

BCs, HT, Anatomic Pathology Supervisor

Al Borg Medical Laboratories

 



More information about the Histonet mailing list