[Histonet] HPV 16/18 background

[Edison Narvaez]

Hello,
I'm running HPV probes from Enzo on my Leica instruments, and we are noticing background episomal pattern on 16/18 staining of cases that are strongly positive for HPV 6/11, but not on cases that are 6/11 or 16/18 negative.
Is anybody experiencing this same issue and are there any suggestions.

I'm using Enzo probes, Enzo Stringency wash, Enzo mouse-antibiotin, and a polymer detection kit.

Thank you








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