[Histonet] CAP ANP.22970 Query

[Joanne Clark]

Hi Histonetters, we are wondering what everyone else out there is doing to be compliant with the following requirement?  We do ER and PR by IHC  but dont know what published benchmarks are out there to compare ourselves to.  Also, how do you record interobserver variability amongst the pathologists?  Any insights into this would be appreciated.



ANP.22970 Annual Result Comparison Phase II
For immunohistochemical and FISH/ISH tests that provide independent predictive
information, the laboratory at least annually compares its patient results with published
benchmarks, and evaluates interobserver variability among the pathologists in the
laboratory.
NOTE: Individuals interpreting the assay must also have their concordance compared with each
other and this concordance should also be at least 95%.
With specific reference to estrogen and progesterone receptor studies: in general, the overall
proportion of ER-negative breast cancers (invasive and DCIS) should not exceed 30%. The
proportion is somewhat lower in postmenopausal than premenopausal women (approximately
20% vs. 35%). The proportion is considerably lower in well-differentiated carcinomas (<10%)
and certain special types of invasive carcinomas (<10% in lobular, tubular, and mucinous types).
The proportion of PgR-negative cases is 10-15% higher than for ER-negative in each of these
settings. Investigation is warranted if the proportion of negative cases is significantly lower in any
of these settings.

Joanne Clark, HT
Director of Histology
Pathology Consultants of New Mexico
Roswell, New Mexico




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