Fw: [Histonet] The Biopsy Chip for high throughput pathology in prostate cancer (and other organs, the list is open..)

Thu Jan 9 11:10:07 CST 2014

On Wednesday, January 8, 2014 10:19 PM, Sorin Musat <s_musat <@t> yahoo.com> wrote: 

Actually, it was easier than expected to convince the urologists to place the biopsies in the grooves of the chip (it did not take longer that the "traditional method" - I timed the first few patients and than it was an easy sell). Particularly since they were provided with a 2-D map of the prostate for them to mark the location of the individual biopsies. 
Of course there is a system of labeling the rows. The first one is dyed in a different color and/or there is a notch at the top left corner. Some people prefer chips with only 6 grooves (so they use one chip for the left lobe, the other one for the right lobe). Others even employ chips for 12 biopsies (one chip=one patient). The nice thing is that the biopsies keep the right orientation with regards to the entry point of the needle and one can easily draw some sort of 3-D representation of the cancer. We do not have here whole slide scanners and the software to do 3D imaging/reconstruction but it should be very easy. Also, even when the biopsy is coming out fragmented, the individual pieces of the biopsy will stay in place and not migrate. If you want, I can send you a presentation with real pictures and some stats on the first 1000 patients who benefited of the Biopsy Chip. A photograph is worth a thousand words. 
Sorin 

On Wednesday, January 8, 2014 9:29 PM, Curt <c.tague <@t> Pathologyarts.com> wrote: 

Interesting, are you having much success convincing the clinician to take the time to us the device? Looks like they might be required to be extremely careful as opposed to just shooting a core into a specimen jar. Also, how about specimen identy/location, are the rows numbered or something along those lines. Something unique about each row to differentiate one from the other? 

Curt 

-----Original Message----- 
From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Sorin Musat 
Sent: Tuesday, January 07, 2014 10:38 PM 
To: histonet <@t> lists.utsouthwestern.edu 
Subject: [Histonet] The Biopsy Chip for high throughput pathology in prostate cancer (and other organs, the list is open..) 

Dear Histoneters, 

I am a new subscriber to Histonet, 
albeit I've been following this great website for at least 10 years. 

I would like to post some information about a new medical device I invented and patented (the Biopsy Chip). 
This device was intended for increasing the efficiency of processing and sectioning prostate biopsies, but can be used for other organs that require multiple biopsies (breast, thyroid, skin, etc.,) as well as for friable tissues (bone marrow). 

For a quick preview, I uploaded on 
youtube a little movie clip we presented at The Romanian Annual Congress of Urology in 2011 (summarizing the results of our first pilot study): 

"High Throughput Biopsy Chip for the detection of Prostate Cancer": 

http://www.youtube.com/watch?v=zP1iiE3CEn0 

After we patented and registered 
the medical device under the authority of the Romanian Ministry of Health, this technique was employed for over 2000 patients so far in a number of Romanian hospitals. We had very good results (significant economies in time and consumables + higher yield of tissue on the slides + more tissue left within the block + increased accuracy of the diagnostic). We already presented a couple of abstracts at 3 Urology conferences and we will publish very soon a full-length paper discussing our results. 

We believe that the Biopsy Chip is the first application of tissue microarrays in clinical diagnostic. Presently we are trying to find collaborators in order to test the Biopsy Chip for other 
organs/pathologies besides prostate cancer. 

We welcome any comments and suggestions. If anyone wants more information about this device I will be very happy to answer your questions. If appropriate, I could also upload a presentation on Histonet server. 

Sincerely 

Sorin Musat, MD, PhD 
THEMIS Pathology (formerly HistoBest Inc, Edmonton, AB, Canada) Bucharest, Romania 
mobile: (4)0768 735 194 / 0725 653 551 
email: s_musat <@t> yahoo.com 
skype: sorin.musat2 
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