[Histonet] Negative Controls in IHC

[Ann Specian]

I have a question in regard to eliminating the use of negative controls when using a non-avidin-biotin detection system.
 
Do you not feel that negative controls may still need to be run in tissues which are likely to be pigmented such as lymph node, skin and liver?
 
We were thinking to eliminate the use of negatives for other tissues (cervical, GI, etc.) only.....What is the general consensus?