[Histonet] RE: Breast Fixation with fixatives other than Formalin

Morken, Timothy Timothy.Morken <@t> ucsfmedctr.org
Mon Jan 23 09:29:50 CST 2012

Carole, The CAP "regs" are recommendations, not regulations. They give you an out to use any other fixative as long as you do a complete validation of the alternative fixative, ie prove the Her2/ER/PR results are identical with the alternative fixative compared to formalin-fixed tissue. That will entail a lot of work on your part but it can be done. 

Tim Morken
Supervisor, Histology, IPOX
UCSF Medical Center
San Francisco, CA, USA

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Carol Fields
Sent: Monday, January 23, 2012 6:48 AM
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] Breast Fixation with fixatives other than Formalin

Hi Netters,
Could you please let me know who all is using breast fixatives other than 10% formalin and what do you do about CAP requirements?  I would also like to get in touch with Dr. Richard Cartun because I think he has done studies on this for Her2. Our docs will not let us use anything other than formalin because of CAP regs and the result is a lot of raw breast tissue.  This is even holding the tissue for a couple days.
Any help with this would be appreciated.
Thank you,

Carole Fields, HT (ASCP)
Histology Supervisor
Northside Hospital
Atlanta, GA 30342
carol.fields <@t> northside.com

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