[Histonet] Underfixation of breast tissue may lead to false results?

Goodwin, Diana dgoodwin <@t> rwjuhh.edu
Wed Mar 23 08:37:32 CDT 2011

Dear Histonetters:

I recently read the following in an article on Medscape:

"Underfixation of breast tissue may lead to false negative ER results and false-positive HER2 results.  In these situations, the tissue is actually fixed in 100% ethanol, which is used to dehydrate the specimens after fixation."

Can anyone explain?

Diana Goodwin
Supervisor, Histology Laboratory
xt. 6996

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