[Histonet] C4d nuclear staining?

[Houston, Ronald]

Has anyone ever noticed any nuclear staining with C4d in a renal biopsy? The control stains great, but the patient's tissue exhibits some nuclear staining in what look to be inflammatory cells. There has been a report of granular and some nuclear staining in lung transplants on structures beyond the vasculature but we haven't seen anything like this in a case of renal rejection.

Ronnie Houston, MS HT(ASCP)QIHC
Anatomic Pathology Manager
ChildLab, a Division of Nationwide Children's Hospital
www.childlab.com

700 Children's Drive
Columbus, OH 43205
(P) 614-722-5450
(F) 614-722-2899
ronald.houston <@t> nationwidechildrens.org<mailto:ronald.houston <@t> nationwidechildrens.org>
www.NationwideChildrens.org<http://www.NationwideChildrens.org>

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