SPAM-LOW: RE: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR - Email found in subject

Tue Oct 12 20:03:08 CDT 2010

The ASCO/CAP Guidelines for ER/Pr may indeed eventually include Her2 but
that has not been published yet as far as I know so we still have to wait
for the 6-72 hr fixation guidelines to be decreed for Her2, now for Her2 it
is 6-48 hours.  They are asking that you record cold ischemic time and time
in fixation for ER/PR and it is sure to come for Her2 so if your staff are
being good at providing that you are ahead of the game.

Regards,

Patsy Ruegg, HT(ASCP)QIHC
IHCtech
12635 Montview Blvd. Ste.215
Aurora, CO 80045
720-859-4060
fax 720-859-4110
www.ihctech.net 
www.ihcrg.org

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Weems, Joyce
Sent: Tuesday, October 12, 2010 12:31 PM
To: Cazares, Ruth; Teri.Hallada <@t> midmichigan.org; Janice.Mahoney <@t> alegent.org;
mpence <@t> grhs.net; Joyce.Cline <@t> wchsys.org; histonet <@t> lists.utsouthwestern.edu
Subject: SPAM-LOW: RE: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for
Her2 and ER/PR - Email found in subject

Yes, but they didn't include HER2 officially. Those guidelines are still to
come is my understanding. 

And then there is documenting the "cold ishemic time". The nursing staff
here have been really good about it. They have to document when it was
removed from the body and when it was put in formalin. There is not much
difference unless it goes for xray before being put in formalin. Always
something new to document!  j

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Cazares,
Ruth
Sent: Tuesday, October 12, 2010 14:18
To: Teri.Hallada <@t> midmichigan.org; Janice.Mahoney <@t> alegent.org;
mpence <@t> grhs.net; Joyce.Cline <@t> wchsys.org; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and
ER/PR - Email found in subject

In the summer of this year, ASCO/CAP issued new guidelines for proper
handling of breast specimens to improve the accuracy of ER and PR status. It
states that the fixation of breast specimens must extend for at least six
hours and no more than 72 hours. It stands to reason that these guidelines
should also stand for Her2 testing. On the second to the last paragraph
before the authors disclaimer it reads,

"We are confident that these guidelines and measures developed for testing
of ER, PgR, and HER2 will improve performance of laboratories using these
and future predictive testing methods."
You can find the guidelines at this website, click on FULL TEXT (on the
right).

www.asco.org/guidelines/erpr

Comments? Opinions? Anyone?

Ruth Cazares, HT (ASCP)
Histology Supervisor
Department of Pathology
Swedish Covenant Hospital
Chicago, IL

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of
Teri.Hallada <@t> midmichigan.org
Sent: Tuesday, October 12, 2010 11:57 AM
To: Janice.Mahoney <@t> alegent.org; mpence <@t> grhs.net; Joyce.Cline <@t> wchsys.org;
histonet <@t> lists.utsouthwestern.edu
Subject: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and
ER/PR - Email found in subject

Sorry Jan,

ASCO/CAP Guideline Recommendations for HER2 in Breast Cancer Article Table
6. Sample Exclusion Criteria to Perform or Interpret a HER2 FISH Assay Item
#3 Tissue fixed for prolonged intervals in formalin (greater than 48 hours)

Teresa Hallada MTCT (ASCP)
MidMichigan Health Gratiot

________________________________

From: histonet-bounces <@t> lists.utsouthwestern.edu on behalf of Mahoney,Janice
A
Sent: Tue 10/12/2010 12:05 PM
To: 'Mike Pence'; Joyce Cline; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR

Formalin fixation time does not impact the results of FISH as it does IHC.
Jan M
Omaha

-----Original Message-----
From: Mike Pence [mailto:mpence <@t> grhs.net]
Sent: Tuesday, October 12, 2010 11:00 AM
To: Mahoney,Janice A; Joyce Cline; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR

I don't think it matters if you do Her2 by FISH or IHC the time is still
48hr. I hope I am wrong, but I don't think I am.

Mike

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of
Mahoney,Janice A
Sent: Tuesday, October 12, 2010 10:25 AM
To: 'Joyce Cline'; histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR

We have decided to reflex to FISH those breasts that do not fall within the
recommended formalin fixation time.  We do work on Saturdays so it is only
the rare 3 day weekends that this comes into play. Jan M Omaha

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Joyce Cline
Sent: Tuesday, October 12, 2010 10:10 AM
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] New Cap Guidelines for Her2 and ER/PR

Does anyone have any experience with storing formalin fixed breast tissue in
70% before processing?  I am trying to comply with the new guidelines set
forth by CAP and ASCO with regard to Her2 and ER/PR and since my lab does
not operate on the weekend we have been well above the
48 hour recommended formalin fixation time.  Does 70% affect antigenicity
for either Her2 or ER/PR?  Any information or suggestions will be greatly
appreciated.  Thanks :)

Ronda Souders
Hagerstown Medical Laboratory
301-665-4980
fax 301-665-4941
ronda.souders <@t> wchsys.org<mailto:ronda.souders <@t> wchsys.org>

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