[SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR - Email found in subject

Cazares, Ruth RCazares <@t> schosp.org
Tue Oct 12 13:17:43 CDT 2010


In the summer of this year, ASCO/CAP issued new guidelines for proper handling of breast specimens to improve the accuracy of ER and PR status. It states that the fixation of breast specimens must extend for at least six hours and no more than 72 hours. It stands to reason that these guidelines should also stand for Her2 testing. On the second to the last paragraph before the authors disclaimer it reads,

"We are confident that these guidelines and measures developed for testing of ER, PgR, and HER2 will improve performance of laboratories using these and future predictive testing methods."
You can find the guidelines at this website, click on FULL TEXT (on the right).

www.asco.org/guidelines/erpr

Comments? Opinions? Anyone?

Ruth Cazares, HT (ASCP)
Histology Supervisor
Department of Pathology
Swedish Covenant Hospital
Chicago, IL



-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Teri.Hallada <@t> midmichigan.org
Sent: Tuesday, October 12, 2010 11:57 AM
To: Janice.Mahoney <@t> alegent.org; mpence <@t> grhs.net; Joyce.Cline <@t> wchsys.org; histonet <@t> lists.utsouthwestern.edu
Subject: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR - Email found in subject

Sorry Jan,

ASCO/CAP Guideline Recommendations for HER2 in Breast Cancer Article
Table 6. Sample Exclusion Criteria to Perform or Interpret a HER2 FISH Assay
Item #3 Tissue fixed for prolonged intervals in formalin (greater than 48 hours)

Teresa Hallada MTCT (ASCP)
MidMichigan Health Gratiot

________________________________

From: histonet-bounces <@t> lists.utsouthwestern.edu on behalf of Mahoney,Janice A
Sent: Tue 10/12/2010 12:05 PM
To: 'Mike Pence'; Joyce Cline; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR



Formalin fixation time does not impact the results of FISH as it does IHC.
Jan M
Omaha

-----Original Message-----
From: Mike Pence [mailto:mpence <@t> grhs.net]
Sent: Tuesday, October 12, 2010 11:00 AM
To: Mahoney,Janice A; Joyce Cline; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR

I don't think it matters if you do Her2 by FISH or IHC the time is still
48hr. I hope I am wrong, but I don't think I am.

Mike

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of
Mahoney,Janice A
Sent: Tuesday, October 12, 2010 10:25 AM
To: 'Joyce Cline'; histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR


We have decided to reflex to FISH those breasts that do not fall within
the recommended formalin fixation time.  We do work on Saturdays so it
is only the rare 3 day weekends that this comes into play. Jan M Omaha

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Joyce
Cline
Sent: Tuesday, October 12, 2010 10:10 AM
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] New Cap Guidelines for Her2 and ER/PR

Does anyone have any experience with storing formalin fixed breast
tissue in 70% before processing?  I am trying to comply with the new
guidelines set forth by CAP and ASCO with regard to Her2 and ER/PR and
since my lab does not operate on the weekend we have been well above the
48 hour recommended formalin fixation time.  Does 70% affect
antigenicity for either Her2 or ER/PR?  Any information or suggestions
will be greatly appreciated.  Thanks :)


Ronda Souders
Hagerstown Medical Laboratory
301-665-4980
fax 301-665-4941
ronda.souders <@t> wchsys.org<mailto:ronda.souders <@t> wchsys.org>

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