[Histonet] Re: Rapid liver core biopsy processing

Sebree Linda A LSebree <@t> uwhealth.org
Fri Aug 27 11:14:32 CDT 2010

Why not do C4d on frozen sections?  That's what we do for our renal bxs
to check for rejection. 

Linda A. Sebree
University of Wisconsin Hospital & Clinics
IHC/ISH Laboratory
DB1-223 VAH
600 Highland Ave.
Madison, WI 53792

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Robert
Sent: Friday, August 27, 2010 11:03 AM
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] Re: Rapid liver core biopsy processing

Garth Fraga, a pathologist at the University of Kansas Medical Center

>>We do about a hundred liver transplants/year at our hospital, and the 
>>hepatologists do lots of liver core biopsies to rule out rejection. 
>>They want a same-day diagnosis on these, so historically they have 
>>been rush processed on a two-hour cycle (VIP machine). They are 
>>brought over directly from the liver biopsy suite immediately after 
>>biopsy, so they get very little fixation in the specimen container 
>>prior to going on the processor. Recently we had a couple of sub-par 
>>cases and have moved to a four-hour processing cycle. Do any of you 
>>have any experience dealing with rush-processed liver cores in 
>>transplant patients? What sort of a processing schedule do you 
>>recommend?  Anyone handling them like frozen sections?<<

I would address this question to the pathologists at the University of
Pittsburgh, since this is the foremost liver transplant service possibly
in the world. I've consulted their Web site about liver transplants -
quite a while ago - and it was quite helpful.

Garth, if you get a reply, could you post it on Histonet for us all to

Bob Richmond
Samurai Pathologist
Knoxville TN

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