[Histonet] Recommended processing schedule for large PMMA specimens?

[Monfils, Paul]

I have some large femur specimens to process for PMMA (approx. 40x40x60 mm).  I have done a fair amount of PMMA work but not with anything this large.  What would you recommend for length of time in absolute alcohol, clearing agent, and PMMA infiltration for specimens this size?  I am performing all these steps under vacuum. Thanks.