Hi I have used the Str-Q-Dots before and after they were provided by Invitrogen. I did not see any signal both manually and automated with ventana machines. If you have results let me know your protocol... Cheers, Mesruh Turkekul Molecular Biologist Memorial Sloan-Kettering Center Molecular Cytology New York, NY 10021 646-8882209\ turkekum <@t> mskcc.org