[Histonet] mitachrondrial disease
rchiovetti <@t> yahoo.com
Sat Dec 22 12:26:27 CST 2007
Is EM a possibility? The mitochondria in patients w/ some of the inherited mito diseases can be really strange-looking. If that's not possible, maybe some special staining can help.
Gomori trichrome or even H&E can show "ragged red fibers" (probably due to the overabundance of mitochondria). Sudan can stain excess lipid (if it's there). Cytochrome oxidase (COX) can be reduced or absent in some mito diseases, and It looks like there can also be differences in succinic dehydrogenase (SDH) staining.
Take a look at:
...just my 2 cents' worth...
Robert (Bob) Chiovetti, Ph.D.
Southwest Precision Instruments
Arizona's Microscopy Resource
132 North Elster Drive
Tucson, AZ 85710-3212
Member, Arizona Small Business Association
----- Original Message ----
From: "pruegg <@t> ihctech.net" <pruegg <@t> ihctech.net>
To: Histonet <histonet <@t> pathology.swmed.edu>
Sent: Friday, December 21, 2007 9:34:57 PM
Subject: [Histonet] mitachrondrial disease
Can someone recommend a histology approach to demonstrate diseased
mitochondria, the investigators I am working with are cardiologist
with genetic defects.
Thank you and happy holidays,
Patsy Ruegg, HT(ASCP)QIHC
Fitzsimmons BioScience Park
12635 Montview Blvd. Suite 215
Aurora, CO 80010
email pruegg <@t> ihctech.net
IHC Resource Group www.ihcrg.org
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