[Histonet] mitachrondrial disease

Robert Chiovetti rchiovetti <@t> yahoo.com
Sat Dec 22 12:26:27 CST 2007


Is EM a possibility?  The mitochondria in patients w/ some of the inherited mito diseases can be really strange-looking.  If that's not possible, maybe some special staining can help.

Gomori trichrome or even H&E can show "ragged red fibers" (probably due to the overabundance of mitochondria).  Sudan can stain excess lipid (if it's there).  Cytochrome oxidase (COX) can be reduced or absent in some mito diseases, and It looks like there can also be differences in succinic dehydrogenase (SDH) staining.

Take a look at:


...just my 2 cents' worth...


Robert (Bob) Chiovetti, Ph.D.

Southwest Precision Instruments
Arizona's Microscopy Resource
132 North Elster Drive
Tucson, AZ 85710-3212
Tel./Fax 520-546-4986
Member, Arizona Small Business Association

----- Original Message ----
From: "pruegg <@t> ihctech.net" <pruegg <@t> ihctech.net>
To: Histonet <histonet <@t> pathology.swmed.edu>
Sent: Friday, December 21, 2007 9:34:57 PM
Subject: [Histonet] mitachrondrial disease

Can someone recommend a histology approach to demonstrate diseased
mitochondria, the investigators I am working with are cardiologist
with genetic defects.

Thank you and happy holidays,





Patsy Ruegg, HT(ASCP)QIHC

IHCtech, LLC

Fitzsimmons BioScience Park

12635 Montview Blvd. Suite 215

Aurora, CO 80010



email pruegg <@t> ihctech.net

website www.ihctech.net

IHC Resource Group www.ihcrg.org 


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