[Histonet] Normal Controls for Cerb-B2

[Bryan Hewlett]

Tony,

The vast majority of normal epithelial cells express HER2 protein on their 
surface.
However, you would not want to use these as a procedural control,
since the objective is to demonstrate OVER-EXPRESSION of this normal 
protein.
Detection of normal levels of HER2 would invalidate the test.

Bryan

----- Original Message ----- 
From: "Tony Henwood" <AnthonyH <@t> chw.edu.au>
To: <Histonet <@t> lists.utsouthwestern.edu>
Sent: Monday, November 20, 2006 12:15 AM
Subject: [Histonet] Normal Controls for Cerb-B2


Hi all,
Apart from Breast and Ovarian tumours (which are rare in pediatric
pathology), does anyone know what normal tissue elements contain this
protein that can be demonstrated using immunohistochemistry?

Regards

Tony Henwood JP, MSc, BAppSc, GradDipSysAnalys, CT(ASC)
Laboratory Manager & Senior Scientist
The Children's Hospital at Westmead,
Locked Bag 4001, Westmead, 2145, AUSTRALIA.
Tel: 612 9845 3306
Fax: 612 9845 3318




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