[Histonet] D2-40 antibody

[Lott, Robert]

Several names for D2-40... one of the most common is podoplanin.

Another is M2A Antigen.

 

The original claim was that it was specific for lymphatic endothelium.
It really does a nice job of staining it and  doesn't stain vascular
endothelium... useful for the diagnosis of lymphangiomas,
lymphangiosarcomas, and determination of lymphatic invasion by neoplasm,
but like a lot of antibodies it stains other things as well.  For
instance, turns out that it is an "excellent" marker for mesotheliomas,
especially the epithelioid type.

 

Follow this link to read an excellent the article about D2-40:
http://www.propathlab.com/pdf/2005-10_D2-40.pdf

 

 

Robert L. Lott, HTL(ASCP)

Manager, Anatomic Pathology

LabFirst / Trinity Medical Center

800 Montclair Road

Birmingham, AL   35213

205-592-5388  phone

205-592-5646  fax

robert.lott <@t> bhsala.com

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From: histonet-bounces <@t> lists.utsouthwestern.edu

[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Sebree

Linda A.

Sent: Tuesday, May 09, 2006 8:13 AM

To: Histonet

Subject: [Histonet] D2-40 antibody

 

One of our residents read about this antibody against lymphatic

endothelium and wondered if its known by another name.  Any help out

there?

 

Linda Sebree, HT(ASCP)

University of Wisconsin Hospital & Clinics

IHC/ISH Laboratory

A4/204-3224

600 Highland Ave.

Madison, WI 53792

(608)265-6596

FAX: (608)262-7174

 




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