[Histonet] mouse antibodies on mouse tissue

[Claudia Freyer]

Dear Histonetter,

I am confused about the use of monoclonal antibodies produced in mice 
against endogenous proteins in mouse tissue. I thought an animal would 
not produce antibodies against its own proteins, since this would 
cause an autoimmune response. Would anybody know why mouse monoclonals 
detect epitopes on mouse proteins?

Many thanks.

Claudia

Dr Claudia Freyer
Prince Henry's Institute of Medical Research
Victoria 
Australia