[Histonet] necrosis detection

[Edwards, R.E.]

for  those  interested  "Classification of cell  death: recommendations of the Nomenclature Committee on Cell Death"  Kroemer et al, Cell Death and Differentiation(2005)12, 1463-1467.

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu]On Behalf Of Ford
Royer
Sent: 19 July 2006 15:39
To: histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] necrosis detection

No  I  don't  think  so..

Bingo... I think that Paul's got it.  Isn't ALL tissue that you look at
necrotic?  (even fresh frozen sections?)  ;-)

~ Ford

Ford M. Royer, MT(ASCP)
Minnesota Medical
Minneapolis, MN

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Monfils,
Paul
Sent: Wednesday, July 19, 2006 9:17 AM
To: 'histonet <@t> lists.utsouthwestern.edu'
Subject: RE: [Histonet] necrosis detection

Necrosis is, technically, cell death. Once a cell is dead, necrosis has
occurred. Autolysis is a post-mortem process whereby dead cells are broken
down by the release of their own autogenous enzymes. So, in the strict
sense, necrosis precedes autolysis. However, necrosis per se cannot be
directly observed. A cell that has just died is still visually identical to
a living cell. What we commonly refer to as "necrosis" in a tissue section
is not merely cell death, but the accumulation of postmortem changes whereby
we can visually identify cells as dead. Such postmortem changes are largely
the result of autolysis. So in that sense "necrosis", or more properly
"necrotic change", results from, rather than precedes, autolysis.



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