[Histonet] AMACR (P504S)

[Richard Cartun]

I agree with Bob Richmond's comments.  Our high molecular weight
cytokeratin (clone 34BetaE12) works beautifully for demonstrating an
absence of basal cells around malignant glands.  We use P504S (from
DAKO) on rare cases.  Their antibody (clone 13H4) is labeled "IVD".  I
know that many labs are running multiple IP stains (HMW-CK, p63, P504S,
and others) on prostate biopsies.  To me, this is completely unnecessary
for the majority of complicated cases where a diagnosis cannot be
established on H&E stains, and is one reason why CMS is proposing MUEs
to limit the number of IP stains that can be performed on a patient's
specimen.

Richard


Richard W. Cartun, Ph.D.
Director, Immunopathology & Histology
Assistant Director, Anatomic Pathology
Hartford Hospital
80 Seymour Street
Hartford, CT  06102
(860) 545-1596
(860) 545-0174 Fax

>>> <Michele_Marggi <@t> ssmhc.com> 02/14/06 11:24AM >>>

I am researching AMACR (P504s) and need some help.  Who out there in
histo-land is using it?  Is this a Research Use Only antibody?  Is a
disclaimer in the report required?  Any input would be
appreciated......

Thanks,

Michele Marggi
Surgical Pathology Supervisor
St. Marys Hospital Medical Center
707 S Mills Street
Madison WI  53715
Telephone: 608.258.6930
Fax: 608.258.6268


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