[Histonet] Chimerism

[Chris Pomajzl]

I can tell you that there is much research being done using chimeric models.
When I was working in research, we had mouse lines that were genetically
engineered as chimeras. This particular lab was testing the role of
heat-shock proteins during cardiac ischemia. I'm not sure if there was any
interesting data obtained from the chimera, but the research possibilities
are fascinating.

Also, there was a TLC or Discovery special not long ago on Chimeras. It was
an interesting program. It is a genetic anomaly that defies logic, but as
Paul stated, it is an organism with two or more genetically distinct cell
populations. Very neat stuff.

----- Original Message ----- 
From: "Paul Bradbury" <histology.bc <@t> shaw.ca>
To: "Kemlo Rogerson" <kemlo.rogerson <@t> waht.swest.nhs.uk>; "HistoNet Server"
<histonet <@t> pathology.swmed.edu>
Sent: Monday, April 10, 2006 9:18 AM
Subject: Re: [Histonet] Chimerism


> Hi Kemlo,
>
> >The only times I have come across chimerism has been associated with
blood transfusion. The patient presents with two different, but apparently
coexisting, cell populations. So my best guess to look for further info
would be the National Blood Transfusion Service, or a similar body. I
believe this is an exceedingly rare condition, but certainly a fascinating
one, should make an interesting thesis topic.
> >
>
> Paul Bradbury
> Kamloops, BC, Canada
>
>
> Kemlo Rogerson wrote:
>
> >I have a student that wants to follow a NVQ (National Vocational
> >Qualification) and has chosen Chimerism (Genetic Mosaicism) about which I
> >know nowt. Does anyone out there know anything about this subject or
anyone
> >who does?
> >
> >I've vainly been trying to find my feminine side and wonder if I've been
> >looking in the wrong place; if this fascinating subject is to be believed
it
> >could, genetically, be anywhere <finds torch>.
> >
> >Kemlo Rogerson
> >Pathology Manager
> >Ext  3311
> >DD   01934 647057
> >Mob 07749 754194
> >
> >
> >
> >
>
> >
> >
> >
> >
> >
> >
> >
>
>
>
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