AW: [Histonet] lymphatics

Andrea T. Hooper anh2006 <@t>
Thu Oct 6 10:11:55 CDT 2005

In the mouse I do not find podoplanin to be specific for lymphatics. 
I gave up on it as it also clearly stained some other fibres in the 
tumor sections we were examining. This could be antibody dependent as 
I only tried it from one source, although a well established source. 
I know believe that Lyve-1+/Prox-1+ doublestaining is the way to go. 
I believe lymphatics are currenlty being described as 
Lyve-1+/Prox-1+/VEGFR-3+/Podoplanin+ although none of these markers 
can be used exclusively for identification - at least in the mouse.

At 4:46 PM +0200 10/6/05, Gudrun Lang wrote:
>I think, Podoplanin is typical for lymphatic endothelcells. We purchase ours
>from Acris, Germany.
>Gudrun Lang


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