[Histonet] Formalin pigment

John Kiernan jkiernan <@t> uwo.ca
Tue Feb 1 10:51:43 CST 2005

Formalin pigment is formed by the action of acid
(pH <5.6) or alkali (pH >8) on haemoglobin. According 
to Lillie's big book (p. 488-489) similar pigment occurs 
around sites of haemorrhage in the gastric mucosa; it's
then called HCl pigment. Malaria pigment is also
closely similar. Lillie cites his own work in the field,
which was published as 3 papers in 1947.
John A. Kiernan
Department of Anatomy and Cell Biology
The University of Western Ontario
London,   Canada   N6A 5C1
"Bruijntjes, J.P." wrote:
> Is there anyone who can tell me what other reason could cause the
> formation of formalin pigment except a too acidic formalin?
> Joost Bruijntjes
> TNO Nutrition and Food research
> Zeist
> The Netherlands
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