[Histonet] nails[Scanned]

[Marshall Terry Dr, Consultant Histopathologist]

What makes clothes soft doesn't necessarily make nails soft. Fabric conditioners work by fluffing out fibres, or at least, stopping them matting.
There be no fibres in toe nails (unless you have a fungal infection).
Some swear by decalcifying fluid, though there be no calcium in nails either.
But, there be water in decalcifying fluid.

Dr Terry L Marshall, B.A.(Law), M.B.,Ch.B.,F.R.C.Path
 Consultant Pathologist
 Rotherham General Hospital
 South Yorkshire
 England
        terry.marshall <@t> rothgen.nhs.uk

-----Original Message-----
From: Kemlo Rogerson [mailto:Kemlo.Rogerson <@t> elht.nhs.uk]
Sent: 05 April 2005 16:06
To: Marshall Terry Dr, Consultant Histopathologist;
Dorothy.L.Webb <@t> HealthPartners.Com; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] nails[Scanned]


Don't think it's just water, I assuming it's something dead scientific that
alters the chemical bonding between proteins; like hydrolysis or something.
I mean what does Fabric conditioner have in it that makes cloths soft?

No I think it's something dead scientific, but I'll be beggared if I know.

-----Original Message-----
From: Marshall Terry Dr, Consultant Histopathologist
[mailto:Terry.Marshall <@t> rothgen.nhs.uk] 
Sent: 05 April 2005 16:00
To: Kemlo Rogerson; Dorothy.L.Webb <@t> HealthPartners.Com;
histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] nails[Scanned]

This business of softening nails continues to intrigue me.
It seems that the only common factor (in all the various protocols) is
water, and that what you are doing is hydrating the nail.
Of course, you then process and dehydrate it.
It remains a mystery.
I remain unconvinced at the utility of any method.
I our hands, nails stay as hard as - well - nails I guess.

Dr Terry L Marshall, B.A.(Law), M.B.,Ch.B.,F.R.C.Path
 Consultant Pathologist
 Rotherham General Hospital
 South Yorkshire
 England
        terry.marshall <@t> rothgen.nhs.uk

-----Original Message-----
From: Kemlo Rogerson [mailto:Kemlo.Rogerson <@t> elht.nhs.uk]
Sent: 05 April 2005 15:49
To: 'Dorothy.L.Webb <@t> HealthPartners.Com';
histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] nails[Scanned]


Fabric softener apparently does it to. Dunno which one, but it apparently
works; wonders if its got Tween in it too? 

-----Original Message-----
From: Dorothy.L.Webb <@t> HealthPartners.Com
[mailto:Dorothy.L.Webb <@t> HealthPartners.Com] 
Sent: 05 April 2005 15:40
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] nails[Scanned]


There is a product from Sigma called "Tween" that works great at both
softening and fixation.  It is a 5% solution in 10% formalin and stays in
there for 24 hours and then processed routinely, cut and placed on a charged
slide and we only stain for PAS unless it has the nailbed with it.  The
order number is P4634.  Good luck!


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