[Histonet] (no subject)

[Richard Cartun]

Complete loss.  You can see patchy immunoreactivity in tumors with these markers. 

Richard

Richard W. Cartun, MS, PhD
Director, Histology & Immunopathology
Director, Biospecimen Collection Programs
Assistant Director, Anatomic Pathology
Hartford Hospital
80 Seymour Street
Hartford, CT  06102
(860) 545-1596 Office
(860) 545-2204 Fax


>>> "Freeman, Carol" <Carol.Freeman <@t> utoledo.edu> 2/16/2012 9:56 AM >>>


Good Morning Histonet,

Ok, We are just starting up with MSI testing in our facility and a
question has popped up about diagnosis of these slides...  Are you
looking for a COMPLETE LOSS of this protein in the tumor, or just a loss
of some expression.?  So if you have a normal piece of tissue staining
uniform and then a tumor of that same tissue showing vague patchy
staining in some cells and a loss in other cells of interest are you
considering that a loss or not.   Does the tumor have to show a COMPLETE
loss of this protein...  Any answer is appreciated.

_______________________________________________
Histonet mailing list
Histonet <@t> lists.utsouthwestern.edu 
http://lists.utsouthwestern.edu/mailman/listinfo/histonet