[SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR - Email found in subject

[Weems, Joyce]

Yes, but they didn't include HER2 officially. Those guidelines are still to come is my understanding. 

And then there is documenting the "cold ishemic time". The nursing staff here have been really good about it. They have to document when it was removed from the body and when it was put in formalin. There is not much difference unless it goes for xray before being put in formalin. Always something new to document!  j

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Cazares, Ruth
Sent: Tuesday, October 12, 2010 14:18
To: Teri.Hallada <@t> midmichigan.org; Janice.Mahoney <@t> alegent.org; mpence <@t> grhs.net; Joyce.Cline <@t> wchsys.org; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR - Email found in subject

In the summer of this year, ASCO/CAP issued new guidelines for proper handling of breast specimens to improve the accuracy of ER and PR status. It states that the fixation of breast specimens must extend for at least six hours and no more than 72 hours. It stands to reason that these guidelines should also stand for Her2 testing. On the second to the last paragraph before the authors disclaimer it reads,

"We are confident that these guidelines and measures developed for testing of ER, PgR, and HER2 will improve performance of laboratories using these and future predictive testing methods."
You can find the guidelines at this website, click on FULL TEXT (on the right).

www.asco.org/guidelines/erpr

Comments? Opinions? Anyone?

Ruth Cazares, HT (ASCP)
Histology Supervisor
Department of Pathology
Swedish Covenant Hospital
Chicago, IL



-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu [mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Teri.Hallada <@t> midmichigan.org
Sent: Tuesday, October 12, 2010 11:57 AM
To: Janice.Mahoney <@t> alegent.org; mpence <@t> grhs.net; Joyce.Cline <@t> wchsys.org; histonet <@t> lists.utsouthwestern.edu
Subject: [SPAM-HC] - RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR - Email found in subject

Sorry Jan,

ASCO/CAP Guideline Recommendations for HER2 in Breast Cancer Article Table 6. Sample Exclusion Criteria to Perform or Interpret a HER2 FISH Assay Item #3 Tissue fixed for prolonged intervals in formalin (greater than 48 hours)

Teresa Hallada MTCT (ASCP)
MidMichigan Health Gratiot

________________________________

From: histonet-bounces <@t> lists.utsouthwestern.edu on behalf of Mahoney,Janice A
Sent: Tue 10/12/2010 12:05 PM
To: 'Mike Pence'; Joyce Cline; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR



Formalin fixation time does not impact the results of FISH as it does IHC.
Jan M
Omaha

-----Original Message-----
From: Mike Pence [mailto:mpence <@t> grhs.net]
Sent: Tuesday, October 12, 2010 11:00 AM
To: Mahoney,Janice A; Joyce Cline; histonet <@t> lists.utsouthwestern.edu
Subject: RE: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR

I don't think it matters if you do Her2 by FISH or IHC the time is still 48hr. I hope I am wrong, but I don't think I am.

Mike

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Mahoney,Janice A
Sent: Tuesday, October 12, 2010 10:25 AM
To: 'Joyce Cline'; histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] RE: New Cap Guidelines for Her2 and ER/PR


We have decided to reflex to FISH those breasts that do not fall within the recommended formalin fixation time.  We do work on Saturdays so it is only the rare 3 day weekends that this comes into play. Jan M Omaha

-----Original Message-----
From: histonet-bounces <@t> lists.utsouthwestern.edu
[mailto:histonet-bounces <@t> lists.utsouthwestern.edu] On Behalf Of Joyce Cline
Sent: Tuesday, October 12, 2010 10:10 AM
To: histonet <@t> lists.utsouthwestern.edu
Subject: [Histonet] New Cap Guidelines for Her2 and ER/PR

Does anyone have any experience with storing formalin fixed breast tissue in 70% before processing?  I am trying to comply with the new guidelines set forth by CAP and ASCO with regard to Her2 and ER/PR and since my lab does not operate on the weekend we have been well above the
48 hour recommended formalin fixation time.  Does 70% affect antigenicity for either Her2 or ER/PR?  Any information or suggestions will be greatly appreciated.  Thanks :)


Ronda Souders
Hagerstown Medical Laboratory
301-665-4980
fax 301-665-4941
ronda.souders <@t> wchsys.org<mailto:ronda.souders <@t> wchsys.org>

________________________________
***** CONFIDENTIALITY NOTICE ***** This message contains confidential information and is intended only for the individual named. If you are not the named addressee you should not disseminate, distribute or copy this e-mail. Please notify the sender immediately by e-mail if you have received this e-mail by mistake and delete this e-mail from your system.
_______________________________________________
Histonet mailing list
Histonet <@t> lists.utsouthwestern.edu
http://lists.utsouthwestern.edu/mailman/listinfo/histonet


Sponsored by Catholic Health Initiatives and Immanuel, Alegent Health is faithful to the healing ministry of Jesus Christ, providing high quality care for the body, mind and spirit of every person.

The information contained in this communication, including attachments, is confidential and private and intended only for the use of the addressees.  Unauthorized use, disclosure, distribution or copying is strictly prohibited and may be unlawful.  If you received this communication in error, please inform us of the erroneous delivery by return e-mail message from your computer.  Additionally, although all attachments have been scanned at the source for viruses, the recipient should check any attachments for the presence of viruses before opening.
Alegent Health accepts no liability for any damage caused by any virus transmitted by this e-mail.  Thank you for your cooperation.


_______________________________________________
Histonet mailing list
Histonet <@t> lists.utsouthwestern.edu
http://lists.utsouthwestern.edu/mailman/listinfo/histonet




Sponsored by Catholic Health Initiatives and Immanuel, Alegent Health is faithful to the healing ministry of Jesus Christ, providing high quality care for the body, mind and spirit of every person.

The information contained in this communication, including attachments, is confidential and private and intended only for the use of the addressees.  Unauthorized use, disclosure, distribution or copying is strictly prohibited and may be unlawful.  If you received this communication in error, please inform us of the erroneous delivery by return e-mail message from your computer.  Additionally, although all attachments have been scanned at the source for viruses, the recipient should check any attachments for the presence of viruses before opening.  Alegent Health accepts no liability for any damage caused by any virus transmitted by this e-mail.  Thank you for your cooperation.


_______________________________________________
Histonet mailing list
Histonet <@t> lists.utsouthwestern.edu
http://lists.utsouthwestern.edu/mailman/listinfo/histonet



___________________________________
Please note that this email message and any attachments may contain privileged and confidential information that is protected against use or disclosure under federal and state law.  The information is intended only for the personal and confidential use of the intended recipient. If the reader of this message is not the intended recipient or the employee or agent responsible for delivering it to the intended recipient, you are hereby notified that you have received this information in error and that any review, dissemination, distribution, copying or action taken in reliance on the contents of this communication is strictly prohibited.  If you have received this email in error, please advise by immediate reply.
_______________________________________________
Histonet mailing list
Histonet <@t> lists.utsouthwestern.edu
http://lists.utsouthwestern.edu/mailman/listinfo/histonet

***  Confidentiality Statement ***
This e-mail is intended only for the use of the individual or entity to which it is addressed and may contain information that is privileged and confidential. If the reader of this message is not the intended recipient, please notify the sender immediately by replying to this message and then delete it from your system. Any review, dissemination, distribution, or reproduction of this message by unintended recipients is strictly prohibited and may be subject to legal restriction.


Thank you for your cooperation.

_______________________________________________
Histonet mailing list
Histonet <@t> lists.utsouthwestern.edu
http://lists.utsouthwestern.edu/mailman/listinfo/histonet
Confidentiality Notice:
This e-mail, including any attachments is the 
property of Catholic Health East and is intended 
for the sole use of the intended recipient(s).  
It may contain information that is privileged and 
confidential.  Any unauthorized review, use,
disclosure, or distribution is prohibited. If you are 
not the intended recipient, please delete this message, and 
reply to the sender regarding the error in a separate email.