Réf. : RE: [Histonet] RE: perfusion debate

Wed Apr 7 08:48:31 CDT 2004

Bonjour!

We tried  measuring the "blood" pressure generated by our perfusion
techniques but were unsuccessful.  Back to  calculating blood volumes,
blood circulation times (using formulas from  vetinarian school documents).
A 35 g mouse, has a blood volume of 1.75 - 2.4 ml (blood volume=
50-80ml/kg) physiological blood flow rates are 6.3 - 8.7 ml/min and
systolic blood pressure of 113 mm Hg.

Conclusions:
Our perfusion rate of 2 ml/min is therefore much lower than physiological
flow rates.

What maximum rates have been used in your experiments (without exploding
the cardiovascular system)?

Nancy Walker
Molecular Pharmacology

Sanofi-Synthelbo Research
B.P. 37 Labége Innopole
31676 LABEGE CEDEX FRANCE

nancy.walker <@t> sanofi-synthelabo.com
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